CJC-1295 has been marketed with and without drug affinity complex (DAC) technology, which extends its half-life and resultant therapeutic window as follows [2]: CJC-1295 No DAC: CJC-1295 No DAC contains only straight CJC-1295 with a D-Ala at the 2-position, a Gln at the 8-position (to reduce asparagine rearrangement), an Ala at position 15 (to enhance bioactivity), and a Leu at position 27 (to prevent methionine oxidation)
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Zonooz SR, Hasani M, Morvaridzadeh M, Pizarro AB, Heydari H, Yosaee S, Rezamand G, Heshmati J (2021) Effect of alpha-lipoic acid on oxidative stress parameters: a systematic review and meta-analysis
Learn More Sigma Aldrich Fine Chemicals Biosciences L-Glutathione reduced|70-18-8 | MFCD00065939 | 5g Supplier: Sigma Aldrich Fine Chemicals Biosciences G42515G L-Glutathione reduced | 98.0% | MW: 307.32 | 70-18-8 | MFCD00065939 | 5g Description By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form
As a key energy substrate for tumor cells, Gln can be catabolized by glutaminase to generate -ketoglutarate (-KG), which directly enters the tricarboxylic acid (TCA) cycle [1]